Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

Author(s): Gennara Cavallaro, Giovanna Pitarresi, Gaetano Giammona.

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 18 , 2011

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Abstract:

In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at proteinlike structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), α,β-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.

Keywords: alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide, alpha,beta-polyaspartylhydrazide, poly(glutamic acid), carriers, anticancer drugs, pharmaceutical field, nanostructured materials, nanotechnologies, drug molecule, polymeric micelles, chemical conjugation, polyaminoacids, thermal polycondensation, polyaspartic acid (PAA), systematic studies, aα,β:-poly(N-2-hydroxyethyl)-DL-aspartamide, α,β:-polyaspartylhydrazide

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Article Details

VOLUME: 11
ISSUE: 18
Year: 2011
Page: [2382 - 2389]
Pages: 8
DOI: 10.2174/156802611797183276
Price: $58

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