What Does the Future Hold for Photo-Oxidizing RuII Complexes with Polyazaaromatic Ligands in Medicinal Chemistry?

Author(s): Jonathan Ghesquiere, Stephane Le Gac, Lionel Marcelis, Cecile Moucheron, Andree Kirsch - De Mesmaeker.

Journal Name: Current Topics in Medicinal Chemistry

Volume 12 , Issue 3 , 2012

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Abstract:

Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for RuII polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of RuII polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing RuII complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed.

Keywords: Diagnostic agent, DNA, oligonucleotide, photo-therapeutic agent, ruthenium, living cells, specific cellular photo-reagents, photo-oxidizing RuII complexes, nucleic acids, luminescent probes, luminophores for biomolecules, hydrophobic complexes, emission wavelengths, cell-viability, gel electrophoresis analyses

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2012
Page: [185 - 196]
Pages: 12
DOI: 10.2174/156802612799079008
Price: $58

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