Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Facile Synthesis, Antibacterial Activity and Molecular Properties Prediction of Some New 1,3-dihydroimidazol-2-thione Derivatives

Author(s): Julfikar Ali Junejo, Surajit Kumar Ghosh, Mutahar Shaikh, Prashant Gahtori, Udaya Pratap Singh.

Abstract:

Present communication deals with the study of antibacterial activity and molecular properties prediction of some new 1,3-dihydroimidazol-2-thione derivatives (1b-6b) obtained by cyclo-condensation reaction between 1-benzoyl- 3-(substituted phenyl) thioureas (A) with triethylamine in the presence of bromine. The structures of these newly synthesized compounds were confirmed by their chemical, spectral and elemental analysis. All the compounds exhibited weak to moderate in-vitro antibacterial activity against representative Gram-positive and Gram-negative microorganisms. It was found that different substitution pattern on core bioactive scaffold 1,3-dihydroimidazol-2-thione causes a dramatic variation in antibacterial profile. Target compounds were further subjected to molecular properties prediction and drug-likeness by Molinspiration and found in compliance with Lipinski ‘ Rule of Five’ (Ro5) and presented a good drug-likeness score with no violations.

Keywords: 1-benzoyl-3-(substituted phenyl) thiourea, Broth dilution method, Disk diffusion, Molecular property, Multidrug resistant microorganisms, Bacillus subtilis, Staphylococcus aureus, anti-thyroid, dopamine- hydroxylase inhibitors, in-vitro antibacterial activity, Antibacterial Activity, Escherichia coli, Gram-negative bacteria, Pseudomonas aeruginosa

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Article Details

VOLUME: 8
ISSUE: 8
Year: 2011
Page: [763 - 768]
Pages: 6
DOI: 10.2174/157018011796575980
Price: $58