Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes
Ahmet Cagri Karaburun,
In this study, some aryl naphtho[2,1-b]furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Antifungal activities of the compounds were tested against Candida albicans (two strains), Candida glabrata, Candida tropicalis and Candida parapsilosis using a microbroth dilution technique. The results showed that the compounds displayed minimum inhibitory concentrations, 7.8-625 µ g/mL.
Keywords: Aryl naphthofuran ketoximes, Aryl naphthofuran O-methylketoximes, Aryl naphthofuran ketoxime acetates, Antifungal activity, Antifungal activities, Candida albicans, Candida glabrata, naphtho[2,1-b]furan-2-yl ketoximes, azole, oxime, diaryl ketoximes, benzofuran-2-yl ketoxime, tetramethylsilane (TMS), Reimer-Tiemann reaction procedure
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