Enantioselective Michael Addition of Malonates to Aromatic α,β-Unsaturated Aldehydes Organocatalyzed by (S)-2-[bis(3,4,5-Trifluorophenyl) trimethylsilanyloxymethyl]pyrrolidine

Author(s): Haiwei Ye , Yemin Zheng , Chuanming Yu , Weihui Zhong .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 7 , 2011

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Abstract:

The Michael addition of malonates to aromatic α,β-unsaturated aldehydes was efficiently organocatalyzed by (S)-2-[bis(3,4,5-trifluorophenyl)trimethylsilanyoxymethyl]pyrrolidine, derived from L-proline to afford the corresponding adducts in good yields with good to excellent enantioselectivities.

Keywords: (S)-2-[bis(3,4,5-trifluorophenyl)trimethylsilanyloxymethyl]pyrrolidin, enantioselectivity, Michael addition, organocatalysis, α,β-unsaturated, aldehydes, malonates, L-proline, pyrrolidinemethanol

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Article Details

VOLUME: 8
ISSUE: 7
Year: 2011
Page: [520 - 525]
Pages: 6
DOI: 10.2174/157017811796504927
Price: $58

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