One-Pot, Solvent Free Synthesis of Hantzsch 1, 4-Dihydropyridines Using β-Cyclodextrin as a Supramolecular Catalyst

Author(s): Dipak R. Patil, Dipak S. Dalal.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 7 , 2011

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Abstract:

A novel, solvent free and efficient one pot synthesis of 1, 4-dihydropyridine derivatives was achieved in good yields via three component reaction of aldehydes, ethyl acetoacetate and ammonium acetate using inexpensive β- cyclodextrin as a supramolecular catalyst. The catalyst can be recovered and reused without loss of activity.

Keywords: 1, 4-dihydropyridine (1, 4-DHPs), hantzsch reaction, one pot condensation, β- Cyclodextrin (β-CD), aldehydes, acetoacetate, ethyl, ammonium, anti-inflammatory agent, bronchodilator

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Article Details

VOLUME: 8
ISSUE: 7
Year: 2011
Page: [477 - 483]
Pages: 7
DOI: 10.2174/157017811796504891
Price: $58

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