Green and One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin- 4(1H)-Ones Promoted by Citric Acid as Recoverable Catalyst in Water

Author(s): Arash Ghorbani-Choghamarani, Tahereh Taghipour.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 7 , 2011

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Citric acid was used as green, non-toxic and reusable catalyst for the preparation of substituted 2,3- dihydroquinazolin-4(1H)ones in high purity and good yields via one-pot three-component reaction of isatoic anhydride with a variety of aldehydes and primary amines or ammonium acetate in water at 80 ° C.

Keywords: 2,3-Dihydroquinazolin-4(1H)-one, catalysis, citric acid, isatoic anhydride, multicomponent reaction, ammonium, acetate, water, amines, antibacterial

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Article Details

Year: 2011
Page: [470 - 476]
Pages: 7
DOI: 10.2174/157017811796505025
Price: $65

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