Treatment of thia analogues of protoberberine alkaloids, 13-carboxy-13,13a-dihydro-6H,8H-isoquinolino [2,3-c][1,3]benzothiazin-8-ones, with thionyl chloride, followed by ethanol, unexpectedly provided 5,11-dioxoindeno [1,2-c]isoquinoline derivatives containing a novel ring system. Elucidation of their structures is presented in this paper. The antiproliferative effects of thiaprotoberberines and indenoisoquinolines were determined by MTT assay against a set of human adherent cancer cell lines (Hela, MCF7 and A431).
Keywords: Benzothiazine, indenoisoquinoline, MTT assay, thia-protoberberine, thionyl, chloride, alkaloids, ethanol, topoisomerases, chromatin
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