Unexpected Formation of Indenoisoquinoline Derivatives from Thia Analogues of Protoberberine Alkaloids

Author(s): Lajos Fodor, Peter Csomos, Judit Molnar, Istvan Zupko, Antal Csampai, Pal Sohar.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 7 , 2011

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Abstract:

Treatment of thia analogues of protoberberine alkaloids, 13-carboxy-13,13a-dihydro-6H,8H-isoquinolino [2,3-c][1,3]benzothiazin-8-ones, with thionyl chloride, followed by ethanol, unexpectedly provided 5,11-dioxoindeno [1,2-c]isoquinoline derivatives containing a novel ring system. Elucidation of their structures is presented in this paper. The antiproliferative effects of thiaprotoberberines and indenoisoquinolines were determined by MTT assay against a set of human adherent cancer cell lines (Hela, MCF7 and A431).

Keywords: Benzothiazine, indenoisoquinoline, MTT assay, thia-protoberberine, thionyl, chloride, alkaloids, ethanol, topoisomerases, chromatin

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Article Details

VOLUME: 8
ISSUE: 7
Year: 2011
Page: [450 - 453]
Pages: 4
DOI: 10.2174/157017811796504981
Price: $58