Thematic Analysis™ : A Chemogenomic Approach to GPCR Drug Discovery

Author(s): Roger Crossley , Jacqueline Anne Macritchie , Martin John Slater .

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 15 , 2011

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Abstract:

Thematic Analysis™ is a chemogenomic tool which has been developed and used to aid the process of GPCR drug discovery. This review covers the scientific rationale behind the development of this tool and provides examples of the successful application of the chemogenomic method in both hit finding and hit to lead stages of the drug discovery process.

Keywords: Chemogenomics, drug discovery, focused libraries, GPCR, library design, Thematic Analysis™, chemogenomic tool, High Throughput Screening (HTS), virtual screening, structure activity relationships (SAR), selection of compounds from a diverse compound set, rational design of a focused library, chemical scaffold

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Article Details

VOLUME: 11
ISSUE: 15
Year: 2011
Page: [1925 - 1943]
Pages: 19
DOI: 10.2174/156802611796391302
Price: $58

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