Abstract
Infection by Streptococcus pneumoniae (the pneumococcus) is associated with enormous morbidity and mortality worldwide and this bacterium remains the commonest cause of pneumonia, meningitis and otitis media. While immunity to pneumococcal disease has been widely accepted to depend mainly on the humoral arm of the immune system recent studies have shown a critical role for cellular immunity, specifically T lymphocytes (T cells), that is independent of antibody, in the prevention and clearance of pneumococcal infection. Here we review the evidence that supports the importance of T cells, specifically CD4+, CD8+ and regulatory T cells, in host responses to pneumococcal infection.
Keywords: Streptococcus pneumoniae, CD4+, CD8+, T cells, Immune Response, cellular immunity, phagocytosis, pneumococcal surface protein A, anti-capsular antibody, B-cells, Cytotoxic
Current Respiratory Medicine Reviews
Title: New Insights into the Immune Response to Pneumococci
Volume: 7 Issue: 4
Author(s): Suzanna E.L. Temple and Phil Hansbro
Affiliation:
Keywords: Streptococcus pneumoniae, CD4+, CD8+, T cells, Immune Response, cellular immunity, phagocytosis, pneumococcal surface protein A, anti-capsular antibody, B-cells, Cytotoxic
Abstract: Infection by Streptococcus pneumoniae (the pneumococcus) is associated with enormous morbidity and mortality worldwide and this bacterium remains the commonest cause of pneumonia, meningitis and otitis media. While immunity to pneumococcal disease has been widely accepted to depend mainly on the humoral arm of the immune system recent studies have shown a critical role for cellular immunity, specifically T lymphocytes (T cells), that is independent of antibody, in the prevention and clearance of pneumococcal infection. Here we review the evidence that supports the importance of T cells, specifically CD4+, CD8+ and regulatory T cells, in host responses to pneumococcal infection.
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Cite this article as:
E.L. Temple Suzanna and Hansbro Phil, New Insights into the Immune Response to Pneumococci, Current Respiratory Medicine Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339811798281188
DOI https://dx.doi.org/10.2174/157339811798281188 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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