Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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New Quinoline-Based Compounds for Analgesic and Anti-Inflammatory Evaluation

Author(s): Rizk Elsayed Khidre, Bakr Fathy Abdel-Wahab, Farid Abdel-Rehem Badria.

Abstract:

In this study, 2-chloroquinolin-3-carbaldehyde 1 was used as a synthon for the synthesis of some new quinoline; pyrane; indeno[1,2-b]pyrano[2,3-b]quinoline heterocycles. The anti-inflammatory and analgesic activities of the synthesized compounds were evaluated using carrageenan-induced paw edema and writhing assays. The obtained data indicated that the majority of the tested compounds exhibited both analgesic and anti-inflammatory activities, particularly compounds 2 and 6 showed a comparable effect to a well known analgesic and anti-inflammatory, diclofenac sodium.

Keywords: Quinoline, Pyranes, Knoevenagel reaction, Analgesic, Anti-inflammatory, X-ray analysis, heterocyclic compounds, 2-chloroquinolin-3-carbaldehydes, synthon, benzoylacetonitrile, NMR spectrum, hot plate test, X-Ray Crystallography, water ad libitum, pyrazole residues

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Article Details

VOLUME: 8
ISSUE: 7
Year: 2011
Page: [640 - 648]
Pages: 9
DOI: 10.2174/157018011796235194
Price: $58