Efficient synthesis of 4H-pyrimido[2,1-b]benzothiazoles by novel one-pot three-component reaction of an aldehyde, β-ketoester and 2-aminobenzothiazole using sulphamic acid as a catalyst is described. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gram-negative bacteria (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa , Bacillus subtilis, Proteus Valgaris). In vitro antifungal activity was also determined against the five fungal species (Aspergillus flavus, Candida albicans Aspergillus fumigatus, Penicillium mareneffei, Chrysosporium tropicum). Structure of the synthesized compounds was established by elemental analysis and spectral data.
Keywords: Multicomponent condensation, 2-Aminobenzothiazole, 4H-Pyrimido[2,1-b]benzothiazoles, Sulphamic acid, Antimicrobial activity, synthesis, Aspergillus flavus, Proteus Valgaris, Gram-positive bacteria, anticonvulsant, analgesic, bis electrophilic reagents, pyrimidine heterocyclic ring system, fungicidal agents, anxiolytic
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