Electrophilic Amination of Organometallic Reagents: Recent Discoveries and Mechanistic Insights

Author(s): David E. Olson.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 8 , Issue 3 , 2011

Abstract:

Electrophilic amination constitutes a unique strategy for the synthesis of C – N bonds. One often-overlooked example of this type of process involves the reaction of organometallic nucleophiles with electrophilic nitrogen sources to yield aryl and alkyl amine derivatives. Such transformations are mechanistically intriguing and have the potential to drastically alter the logic by which nitrogencontaining compounds are synthesized.

Keywords: Amination, C, –, N bonds, electrophilic nitrogen, mechanism, organometallic reagents, umpolung

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [341 - 346]
Pages: 6
DOI: 10.2174/157019311796197391
Price: $58

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