Generation of Regulatory T Cells to Antigen Expressed in the Retina

Author(s): Scott W. McPherson, Neal D. Heuss, Ute Lehmann, Dale S. Gregerson.

Journal Name: Current Immunology Reviews

Volume 7 , Issue 3 , 2011

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Abstract:

Regulatory T cells (Tregs) are generated to antigens (Ag) found in the retina. Some Tregs are the result of ectopic expression of the retinal Ags in the thymus, where developing T cells are committed to enter the regulatory lineage. However, the generation of retinal Ag-specific Tregs independent of the thymus was uncertain. Our studies show that Tregs can be generated from mature, peripheral T cells based on exposure to retinal Ags. These peripherally induced Tregs limited immune responses and experimental autoimmune disease induced by retinal Ags and thus constitute a crucial component of retinal immune privilege.

Keywords: Regulatory T cells, immune privilege, retina, Tregs, Ocular immune regulation, ocular tissue, Retinal Ags, Tregs mediated immune regulation, DTH response, immunoregulation

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2011
Page: [344 - 349]
Pages: 6
DOI: 10.2174/157339511796196584
Price: $58

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