89Zr Radiochemistry for Positron Emission Tomography

Author(s): Gregory W. Severin, Jonathan W. Engle, Todd E. Barnhart, R. Jerry Nickles.

Journal Name:Medicinal Chemistry

Volume 7 , Issue 5 , 2011

Abstract:

The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.

Keywords: 89Zr, zirconium-89, positron emission tomography, desferal, Immuno-PET, desferrioxamine, mAbs, monoclonal antibodies, cyclotron physics, yttrium target material, bifunctional chelate, desferrioxamine B

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2011
Page: [389 - 394]
Pages: 6
DOI: 10.2174/157340611796799186
Price: $58