89Zr Radiochemistry for Positron Emission Tomography
Gregory W. Severin, Jonathan W. Engle, Todd E. Barnhart and R. Jerry Nickles
Affiliation: 1111 Highland Ave. Madison WI 53705, USA.
The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.
Keywords: 89Zr, zirconium-89, positron emission tomography, desferal, Immuno-PET, desferrioxamine, mAbs, monoclonal antibodies, cyclotron physics, yttrium target material, bifunctional chelate, desferrioxamine B
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