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Medicinal Chemistry
ISSN (Print): 1573-4064
ISSN (Online): 1875-6638
VOLUME: 7
ISSUE: 5
DOI: 10.2174/157340611796799186      Price:  $58









89Zr Radiochemistry for Positron Emission Tomography

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Author(s): Gregory W. Severin, Jonathan W. Engle, Todd E. Barnhart and R. Jerry Nickles
Pages 389-394 (6)
Abstract:
The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.
Keywords:
89Zr, zirconium-89, positron emission tomography, desferal, Immuno-PET, desferrioxamine, mAbs, monoclonal antibodies, cyclotron physics, yttrium target material, bifunctional chelate, desferrioxamine B
Affiliation:
1111 Highland Ave. Madison WI 53705, USA.