Recent Progress in the Development of Natural ent-Kaurane Diterpenoids with Anti-tumor Activity

Author(s): L. Wang, D. Li, C. Wang, Y. Zhang, J. Xu.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 10 , 2011

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Abstract:

The ent-kaurane diterpenoids are widely distributed in China, some of which have high natural abundance in plants of Isodon, Pteris, Gnaphalium, Diplospora, Croton and some other species. These compounds exhibit significant anti-tumor, antibacterial and anti-inflammatory activities, which have attracted the attention of medicinal chemists. This review focuses on the recent advances in the research of derivatives, anti-tumor activity, mechanism of action, and structure- activity relationships of ent-kaurane diterpenoids. All of these will show the potential in the development of new antitumor agents in natural products.

Keywords: ent-kaurane, diterpenoids, derivatives, anti-tumor activity, mechanism of action, structure-activity relationships, China, Isodon, antibacterial, natural products

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Article Details

VOLUME: 11
ISSUE: 10
Year: 2011
Page: [910 - 919]
Pages: 10
DOI: 10.2174/138955711796575416
Price: $58

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