Therapeutic Interventions to Renin-Angiotensin-Aldosterone System, and Vascular Redox State

Author(s): Nikolaos Koumallos , Georgios Nteliopoulos , Andreas Paschalis , Ioannis Dimarakis , Nizar Yonan .

Journal Name: Recent Patents on Cardiovascular Drug Discovery (Discontinued)

Volume 6 , Issue 2 , 2011

Abstract:

It is well established that RAS plays a key role in the development of hypertension, cardiovascular and renal disease. On the other hand oxidative stress is a key feature in vascular homeostasis. Many of the cellular effects of Ang II appear to be mediated by ROS generated by NAD(P)H oxidase. In this review, we provide an overview of ROS physiology in human vessels especially in relation with RAS. We also discuss how therapeutic interventions on RAS affect redox signaling in the vascular wall at a clinical level with the discussion of recent patents.

Keywords: Oxidative stress, RAS, redox signaling, angiotensin-converting enzyme inhibitors, Plasma renin activity, β blocker, Janus kinase, Renin, angiotensin system, Reactive Oxygen Species, Tissue necrosis factor, Mineralocorticoid receptor antagonists

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2011
Page: [115 - 122]
Pages: 8
DOI: 10.2174/157489011795933864
Price: $100

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