Abstract
Biomolecular computation and synthetic biology are the main disciplines in the design and implementation of biological computing devices. This article examines some of the key works concerning this type of logical devices processing biological information. Their design and construction follow two main approaches. The first approach builds computing devices based on the properties of nucleic acids, whereas the second approach focuses on genetic regulatory networks. Examples of the nucleic acid based approach are DNA self-assembly, DNA automata based on restriction enzymes or deoxyribozymes and logic circuits based on DNA strand displacement. Examples of the use of genetic networks are NOT, AND and OR logic gates, a genetic toggle switch that works like a biological memory unit, and several genetic oscillators that work as biological clocks.
Keywords: DNA computing, biomolecular computation, synthetic biology, genetic circuit, strand displacement, molecular automata, nucleic acids, enzymes, DNA molecules, Genetic Oscillators
Current Bioinformatics
Title: Biomolecular Computers
Volume: 6 Issue: 2
Author(s): Inaki Sainz de Murieta, Jesus M. Miro-Bueno and Alfonso Rodriguez-Paton
Affiliation:
Keywords: DNA computing, biomolecular computation, synthetic biology, genetic circuit, strand displacement, molecular automata, nucleic acids, enzymes, DNA molecules, Genetic Oscillators
Abstract: Biomolecular computation and synthetic biology are the main disciplines in the design and implementation of biological computing devices. This article examines some of the key works concerning this type of logical devices processing biological information. Their design and construction follow two main approaches. The first approach builds computing devices based on the properties of nucleic acids, whereas the second approach focuses on genetic regulatory networks. Examples of the nucleic acid based approach are DNA self-assembly, DNA automata based on restriction enzymes or deoxyribozymes and logic circuits based on DNA strand displacement. Examples of the use of genetic networks are NOT, AND and OR logic gates, a genetic toggle switch that works like a biological memory unit, and several genetic oscillators that work as biological clocks.
Export Options
About this article
Cite this article as:
Sainz de Murieta Inaki, M. Miro-Bueno Jesus and Rodriguez-Paton Alfonso, Biomolecular Computers, Current Bioinformatics 2011; 6 (2) . https://dx.doi.org/10.2174/1574893611106020173
DOI https://dx.doi.org/10.2174/1574893611106020173 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Emerging Concepts on Inhibitors of Indoleamine 2,3-Dioxygenase in Rheumatic Diseases
Current Medicinal Chemistry Editorial [Hot topic: Modifying Cardiovascular Risk Factors: Epidemiology and Characteristics of Smoking-Related Cardiovascular Diseases (Executive Editor: Aurelio Leone)]
Current Pharmaceutical Design Human Mesenchymal Stem Cells (hMSCs) as Targets of DNA Damaging Agents in Cancer Therapy
Current Cancer Drug Targets Antiphospholipid Antibody-Mediated Thrombotic Mechanisms in Antiphospholipid Syndrome: Towards Pathophysiology-Based Treatment
Current Pharmaceutical Design Gestational Diabetes and the Metabolic Syndrome: Can Obesity and Small, Dense Low Density Lipoproteins be Key Mediators of this Association?
Current Pharmaceutical Biotechnology Hemangiomas, Angiosarcomas, and Vascular Malformations Represent the Signaling Abnormalities of Pathogenic Angiogenesis
Current Molecular Medicine An Update in the Development of HIV Entry Inhibitors
Current Topics in Medicinal Chemistry Randomized Clinical Trials in Children - Ethical and Methodological Issues
Current Pharmaceutical Design Nenatal Drug Induced Nephrotoxicity : Old and Next Generation Biomarkers for Early Detection and Management of Neonatal Drug-Induced Nephrotoxicity, with Special Emphasis on uNGAL and on Metabolomics
Current Medicinal Chemistry Passive Smoking, Asthma and Allergy in Children
Inflammation & Allergy - Drug Targets (Discontinued) Targeting Potassium Channels: New Advances in Cardiovascular Therapy
Recent Patents on Cardiovascular Drug Discovery Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer
Current Cancer Drug Targets Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy
Current Drug Targets Additive Effect of MCP in Combination with Cefotaxime Against Staphylococcus aureus
Medicinal Chemistry Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157
Current Medicinal Chemistry The Use of Nitric Oxide Synthase Inhibitors in Inflammatory Diseases: A Novel Class of Anti-Inflammatory Agents
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Glucose Blood Levels as a Therapeutic Target in Acute Ischaemic Stroke Setting
Current Topics in Medicinal Chemistry Activation of the Innate Immune System in Atherosclerotic Disease
Current Pharmaceutical Design Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Investigation of Nanoemulsion System for Transdermal Delivery of Domperidone: Ex-vivo and in vivo Studies
Current Nanoscience