Abstract
In recent years the development of small organic molecules modulating protein-protein interactions (P-PIs) has drawn major attention in both academic and industrial research. Despite the appreciable progress being made, targeting such extensive interaction areas with comparatively small, drug-like agents has proven to be an ambitious objective. This review highlights the reasons rendering this task highly challenging and provides an overview on the latest developments in rational design approaches for P-PI modulators. The significance, scope and limitations of computational methods in this particular field of research are analyzed. Recent successfully identified and designed P-PI modulators are discussed. Thereby, particular focus is taken on small organic molecules disrupting protein-protein interfaces of protein kinases.
Keywords: Protein-protein interactions, protein-protein interaction modulators, virtual screening, rational drug design, protein kinases, molecular modeling, drug-like agents, vascular endothelial growth factor (VEGF), affinity, alanine scanning mutagenesis, Molecular Mechanics Poisson-Boltzmann/surface area (MM-PBSA)approach, LIE (linear interaction energy) models, FEP, thermodynamic integration (TI), electrostatic effects
Current Topics in Medicinal Chemistry
Title: Modulators of Protein-Protein Interactions – Novel Approaches in Targeting Protein Kinases and Other Pharmaceutically Relevant Biomolecules
Volume: 11 Issue: 11
Author(s): Rechfeld Florian, Peter Gruber, Johann Hofmann and Johannes Kirchmair
Affiliation:
Keywords: Protein-protein interactions, protein-protein interaction modulators, virtual screening, rational drug design, protein kinases, molecular modeling, drug-like agents, vascular endothelial growth factor (VEGF), affinity, alanine scanning mutagenesis, Molecular Mechanics Poisson-Boltzmann/surface area (MM-PBSA)approach, LIE (linear interaction energy) models, FEP, thermodynamic integration (TI), electrostatic effects
Abstract: In recent years the development of small organic molecules modulating protein-protein interactions (P-PIs) has drawn major attention in both academic and industrial research. Despite the appreciable progress being made, targeting such extensive interaction areas with comparatively small, drug-like agents has proven to be an ambitious objective. This review highlights the reasons rendering this task highly challenging and provides an overview on the latest developments in rational design approaches for P-PI modulators. The significance, scope and limitations of computational methods in this particular field of research are analyzed. Recent successfully identified and designed P-PI modulators are discussed. Thereby, particular focus is taken on small organic molecules disrupting protein-protein interfaces of protein kinases.
Export Options
About this article
Cite this article as:
Florian Rechfeld, Gruber Peter, Hofmann Johann and Kirchmair Johannes, Modulators of Protein-Protein Interactions – Novel Approaches in Targeting Protein Kinases and Other Pharmaceutically Relevant Biomolecules, Current Topics in Medicinal Chemistry 2011; 11 (11) . https://dx.doi.org/10.2174/156802611795589610
DOI https://dx.doi.org/10.2174/156802611795589610 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Disruptive Nanozyme Technology for Futuristic Bio-Medical and Bio-imaging Applications
Current Nanoscience Inflammation and Antiangiogenesis in Cancer
Current Medicinal Chemistry Reducing the Burden of Cervical Cancer in the Developing World
Current Women`s Health Reviews The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery
Current Topics in Medicinal Chemistry How to Manage the Infectious Risk under Anti-TNF in Inflammatory Bowel Disease
Current Drug Targets Carbon Nanotubes in the Treatment of Skin Cancers: Safety and Toxic ological Aspects
Pharmaceutical Nanotechnology The Structure and Function of Histone Deacetylases: The Target for Anti-cancer Therapy
Current Medicinal Chemistry Coexistence of Hodgkin and Non-Hodgkin Lymphoma; Composite Lymphoma [CL] in a Patient Presenting with Waxing and Waning Lymphadenopathy
Cardiovascular & Hematological Disorders-Drug Targets The Role of Saffron in Attenuating Age-related Oxidative Damage in Rat Hippocampus
Recent Patents on Food, Nutrition & Agriculture TGF-ß / Smad Signaling in Prostate Cancer
Current Drug Targets Detection and Specific Targeting of Hypoxic Regions within Solid Tumors: Current Preclinical and Clinical Strategies
Current Medicinal Chemistry Ultrasound Assisted Synthesis of 2-Substituted Benzofurans via One-Pot and Sequential Method: Their In Vitro Evaluation
Anti-Cancer Agents in Medicinal Chemistry Unknown Primary Squamous Cell Carcinoma of the Head and Neck
Current Cancer Therapy Reviews Microneedle Patches as Drug and Vaccine Delivery Platform
Current Medicinal Chemistry Cytochrome P450 Gene Polymorphism and Cancer
Current Drug Metabolism Cranberry as Promising Natural Source of Potential Anticancer Agents: Current Evidence and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry Anal Carcinoma
Current Cancer Therapy Reviews Targeted Multimodal Liposomes for Nano-delivery and Imaging: An Avenger for Drug Resistance and Cancer
Current Gene Therapy Chemical Constituents of Plants from the Genus Valeriana
Mini-Reviews in Organic Chemistry Eriocalyxin B-Induced Apoptosis in Pancreatic Adenocarcinoma Cells Through Thiol-Containing Antioxidant Systems and Downstream Signalling Pathways
Current Molecular Medicine