Inflammation & Allergy-Drug Targets

(Formerly Current Drug Targets - Inflammation & Allergy)

Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448


Nasal Polyposis: From Pathogenesis to Treatment, An Update

Author(s): Manuele Casale, Marco Pappacena, Massimiliano Potena, Emanuela Vesperini, Giacomo Ciglia, Ranko Mladina, Caterina Dianzani, Anna Marta Degener and Fabrizio Salvinelli

Affiliation: Area of Otolaryngology, Campus Bio-Medico University, Via Alvaro del Portillo 21, 00128 Rome, Italy.


Nasal polyps (NP) are common benign degeneration of nasal sinus mucosa with a prevalence around 4% in the adult population. The causes are still uncertain but there is a strong association with allergy, infection, asthma and aspirin sensitivity. Histologically, the presence of a large quantity of extracellular fluid, mast cell degranulation and eosinophilia has been demonstrated. Typically the patients show nasal obstruction, anosmia and rhinorrhoea. Nasal endoscopic examination and CT imaging allow evaluation of the disease extention.

A combined medical and surgical treatment is recommended for symptoms control in preventing symptomatic NP recurrence. We will review the current knowledge in the pathogenesis and treatment of this complex disease entity.

Keywords: Nasal polyposis, rhinosinusitis, allergy, eosinophils, functional endoscopic sinus surgery, nasal obstruction, anosmia, aspirin asensitivity, Nasal endoscopic examination, hyposmia

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Article Details

Page: [158 - 163]
Pages: 6
DOI: 10.2174/187152811795564055