The progress of development in chiral Lewis acid catalyzed reaction in water is described. Lewis acid surfactant-combined catalyst and chiral bipyridine ligand complex realized catalytic asymmetric hydroxymethylation and ring-opening reaction in water successfully. Furthermore, silica-supported Lewis acid catalyst was applied for asymmetric hydroxylation in water.
Keywords: Aldol reaction, Chiral Lewis acid, Epoxide, Green chemistry, Lewis acid, Mannich reaction, Water, asymmetric, organic, solvents
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