Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Novel Coumarin and 4H-Chromene Derivatives Containing 4,5- Dihydropyrazole Moiety: Synthesis and Antibacterial Activity

Author(s): Qian-Zhu Li, Xiao-Yan Nie, Jie Liang.

Abstract:

Seven novel 6-(1-acetyl-3-(6-substituted-2-oxo-2H-chromen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)-2-amino-4- substituted-4H-chromene-3-carbonitrile derivatives were synthesized and characterized by 1H NMR and 13C NMR. All of the compounds have been screened for their antibacterial activity. The results show that compounds 4d and 4g displayed significant activity with MIC of 1.562 μg/mL against B. subtilis ATCC 6633 and 1.562, 3.125 μg/mL against S. aureus ATCC 6538.

Keywords: Coumarin, Dihydropyrazole, 4H-chromene, Antibacterial activity, 4,5-Dihydropyrazole, Moiety, Multidrug resistance, benzopyridone, B. subtilis ATCC 6633, E. coli ATCC 35218, P. aeruginosa

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2011
Page: [558 - 561]
Pages: 4
DOI: 10.2174/157018011795906857
Price: $58