Synthesis of N-glycopeptides Applying Glycoamino Acid Building Blocks with a Combined Fmoc/Boc Strategy

Author(s): Kinga Rakosi, Orsolya Szolomajer-Csikos, Laszlo Kalmar, Zoltan Szurmai, Janos Kerekgyarto, Gabor K. Toth.

Journal Name:Protein & Peptide Letters

Volume 18 , Issue 7 , 2011

Abstract:

Mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated into Leu-Lys-Asn-Gly-Gly-Pro hexapeptide that is a partial structure of the Trp-cage mini-protein by linear assembly. These studies provide evidence that the used combination of Fmoc and Boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield.

Keywords: Carbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chlorideCarbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chloride

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Article Details

VOLUME: 18
ISSUE: 7
Year: 2011
Page: [679 - 683]
Pages: 5
DOI: 10.2174/092986611795446003
Price: $58