Synthesis of N-glycopeptides Applying Glycoamino Acid Building Blocks with a Combined Fmoc/Boc Strategy
Kinga Rakosi, Orsolya Szolomajer-Csikos, Laszlo Kalmar, Zoltan Szurmai, Janos Kerekgyarto and Gabor K. Toth
Pages 679-683 (5)
Mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated into Leu-Lys-Asn-Gly-Gly-Pro hexapeptide that is a partial structure of the Trp-cage mini-protein by linear assembly. These studies provide evidence that the used combination of Fmoc and Boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield.
Carbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chlorideCarbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chloride
Department of Medical Chemistry, Faculty of General Medicine, University of Szeged, 6720 Szeged Dom ter 8., Hungary.