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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 18
ISSUE: 7
DOI: 10.2174/092986611795446003      Price:  $58









Synthesis of N-glycopeptides Applying Glycoamino Acid Building Blocks with a Combined Fmoc/Boc Strategy

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Author(s): Kinga Rakosi, Orsolya Szolomajer-Csikos, Laszlo Kalmar, Zoltan Szurmai, Janos Kerekgyarto and Gabor K. Toth
Pages 679-683 (5)
Abstract:
Mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated into Leu-Lys-Asn-Gly-Gly-Pro hexapeptide that is a partial structure of the Trp-cage mini-protein by linear assembly. These studies provide evidence that the used combination of Fmoc and Boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield.
Keywords:
Carbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chlorideCarbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chloride
Affiliation:
Department of Medical Chemistry, Faculty of General Medicine, University of Szeged, 6720 Szeged Dom ter 8., Hungary.