Mini-Reviews in Medicinal Chemistry

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Renal Heat Shock Proteins Over-Expression Due to Anabolic Androgenic Steroids Abuse

Author(s): S. D'Errico, B. Di Battista, M. Di Paolo, C. Fiore and C. Pomara

Affiliation: Department of Forensic Pathology, University of Foggia, viale degli Aviatori 1,71100 Foggia, Italy.

Keywords: Anabolic androgenic steroid, double contour membrane, fibrinogen, focal segmental glomerulosclerosis, heat shock protein, nephrotoxicity, Over-Expression, Abuse, HSPs toxic agents, chaperones, Renal

Abstract:

Chronic use of anabolic adrogenic steroids (AAS) has been known to cause serious adverse effects. While the effects of AASs on cardiovascular system are well known, toxicity on other organs has received less attention. A doserelated nephrotoxic effect has been proposed and a wide variety of morpho-functional damages have been observed, but , the exact pathophysiological mechanism of action is still not well known. In the present minireview, we highlight the remaining issues through an analysis of the pertinent literature. As with HSPs toxic agents their overexpression could be considered a protective reaction against AAS abuse however, comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after long term use of AAS are needed.

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Article Details

VOLUME: 11
ISSUE: 5
Page: [446 - 450]
Pages: 5
DOI: 10.2174/138955711795445934