Abstract
Quantitative structure activity relationship approach using enhanced replacement method for variable selection was applied to a series of imidazole containing tetrahydrobenzodiazepines as inhibitors of farnesyltransferase. For the purpose the dataset was divided into training set of 31 compounds and test set of 5 compounds using k means clustering. Statistically significant equations were obtained with high correlation coefficient coefficient (R=0.9637) and low standard deviation (S=0.3715). The robustness of the model was confirmed with the help of R2cv with a value of 0.8886, Y scrambling and by predicting the activities of test compounds. A good correlation of KierA3 shape indices and polarizability with the farnesyltransferase inhibitory activity was achieved.
Keywords: QSAR, Farnesyltransferase Inhibitors, Tetrahydrobenzodiazepines, Y scrambling, Polarizability, Imidazole, Ras proteins, PFT inhibitors, metalloenzyme, GABAA, Kubinyi function (FIT), apol, Specific Polarizability, Spol(R4)
Letters in Drug Design & Discovery
Title: Exploring the Structure Activity Relationships of Imidazole Containing Tetrahydrobenzodiazepines as Farnesyltransferase Inhibitors: A QSAR Study
Volume: 8 Issue: 6
Author(s): Anand Gaurav, Vertika Gautam and Ranjit Singh
Affiliation:
Keywords: QSAR, Farnesyltransferase Inhibitors, Tetrahydrobenzodiazepines, Y scrambling, Polarizability, Imidazole, Ras proteins, PFT inhibitors, metalloenzyme, GABAA, Kubinyi function (FIT), apol, Specific Polarizability, Spol(R4)
Abstract: Quantitative structure activity relationship approach using enhanced replacement method for variable selection was applied to a series of imidazole containing tetrahydrobenzodiazepines as inhibitors of farnesyltransferase. For the purpose the dataset was divided into training set of 31 compounds and test set of 5 compounds using k means clustering. Statistically significant equations were obtained with high correlation coefficient coefficient (R=0.9637) and low standard deviation (S=0.3715). The robustness of the model was confirmed with the help of R2cv with a value of 0.8886, Y scrambling and by predicting the activities of test compounds. A good correlation of KierA3 shape indices and polarizability with the farnesyltransferase inhibitory activity was achieved.
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Cite this article as:
Gaurav Anand, Gautam Vertika and Singh Ranjit, Exploring the Structure Activity Relationships of Imidazole Containing Tetrahydrobenzodiazepines as Farnesyltransferase Inhibitors: A QSAR Study, Letters in Drug Design & Discovery 2011; 8 (6) . https://dx.doi.org/10.2174/157018011795906758
DOI https://dx.doi.org/10.2174/157018011795906758 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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