Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Range of Derivatives of 2-imidazol-1-yl-1-phenyl-ethanone as Potential Novel Inhibitors of 17α-hydroxylase/17,20-lyase (P-45017α)

Author(s): Kruti Shah, Baljeet Jandu, Ammara Abdullah, Sabbir Ahmed.

Abstract:

We report the results of the evaluation of a series of imidazole-based compounds against the enzyme 17α- hydroxylase/17,20-lyase (P-45017α). The results show that the compounds were, in general, weak inhibitors of P-45017α in comparison to the standard inhibitor ketoconazole (KTZ) - one was, however, found to be more potent than KTZ.

Keywords: Androgen, Enzyme inhibitor, 17α-hydroxylase, Imidazole, 17,20-lyase, Prostate cancer, Biochemical, 2-imidazol-1-yl-1-phenyl-ethanone, P-45017α, cytochrome, androstenedione (AD), dehydroepiandrosterone (DHEA), progesterone, pregnenolone, NADPH, iron-monooxygen

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2011
Page: [516 - 522]
Pages: 7
DOI: 10.2174/157018011795906749
Price: $58