A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides

Author(s): Haitao Yang, Zhiwei Miao, Ruyu Chen.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 5 , 2011

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Abstract:

A copper-catalyzed coupling reaction of aryl halides with various aromatic cyclic secondary amines in DMSO has been developed efficiently. The versatile and efficient copper catalyst system is of wide-spread and practical application in cross-coupling reactions.

Keywords: N-Arylation, Aromatic cyclic secondary amines, Copper catalyst, Cross-coupling, pharmaceutical, heterocycle, dioxane, toluene, dichloroethane, aryl halide

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2011
Page: [325 - 331]
Pages: 7
DOI: 10.2174/157017811795684974
Price: $58

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