A series of novel substituted γ-amino acids has been catalytically prepared by a one-pot reaction of substituted imines and homoenolates. The efficiency of the novel direct route has been found to depend on the nature of amine being either aliphatic or aromatic. Additionally, the influence of aromatic substituents has been investigated.
Keywords: γ-amino acid, homoenolate, imines, lewis acid, peptidases, homoaldol reaction, hydroxy, carbonyl, biodegradation, homoenolates
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