Black Light Induced Radical Cyclization Approach to Cyclonucleosides: An Independent Approach

Author(s): Victoria T. Perchyonok.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 5 , 2011

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Abstract:

The paper highlights an efficient methodology based on consecutive radical reaction for the preparation of cyclonucleoside derivatives. The reactions were performed in organic and aqueous media, using common and efficient free radical hydrogen donors in the range of innovative and conventional initiation conditions to afford good to excellent yields of corresponding cyclonucleosides. The mechanistic aspects of the transformations are also addressed.

Keywords: Cyclo-nucleosides, black light, aqueous media, free radical reactions, dihydrothymidine, deoxyribose, chromatographic, diastereoisomers, oligonucleotides, cyclopyrimidine

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2011
Page: [337 - 340]
Pages: 4
DOI: 10.2174/157017811795685108
Price: $58

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