The paper highlights an efficient methodology based on consecutive radical reaction for the preparation of cyclonucleoside derivatives. The reactions were performed in organic and aqueous media, using common and efficient free radical hydrogen donors in the range of innovative and conventional initiation conditions to afford good to excellent yields of corresponding cyclonucleosides. The mechanistic aspects of the transformations are also addressed.
Keywords: Cyclo-nucleosides, black light, aqueous media, free radical reactions, dihydrothymidine, deoxyribose, chromatographic, diastereoisomers, oligonucleotides, cyclopyrimidine
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