Facile Catalyst-Free Allylation of Isatins Under Mild Conditions in Dimethylformamide

Author(s): Li-Na Jia, Lin Peng, Liang-Liang Wang, Jian-Fei Bai, Ji-Ya Fu, Qing-Chun Huang, Fei-Ying Wang, Xiao-Ying Xu, Li-Xin Wang*.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 5 , 2011

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The catalyst-free allylation of isatins with allyltrichlorosilane was performed smoothly in DMF under mild conditions and moderate to excellent yields (60%-94%) were obtained. This protocol provided a new and efficient approach for the preparation of 3-allyl-3-hydroxy-2-oxindoles.

Keywords: Allylation, isatin, allyltrichlorosilane, 3-allyl-3-hydroxy-2-oxindoles, catalyst-free, hydroxyglucoisatisins, convulutamydines, donaxaridines, HIV protease inhibitor, welwitindoline

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Article Details

Year: 2011
Page: [352 - 357]
Pages: 6
DOI: 10.2174/157017811795685072
Price: $58

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