Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates

Author(s): S. S. Ebada, P. Proksch.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 3 , 2011

Submit Manuscript
Submit Proposal

Abstract:

Natural Guanidines from marine invertebrates represent a group of bioactive secondary metabolites that revealed prominent pharmacological activities such as antimicrobial, antiproliferative, analgesic, and anticoagulant properties. Acyclovir (Zovirax®), the first guanidine-derived pharmaceutical for the treatment of herpes infections since late 1970s, was synthesized based on a marine arabinosyl nucleoside, spongosine. Recently, ziconotide (Prialt®), a synthetic form of the marine-derived peptide (ω-conotoxin MVIIA) comprising a guanidine moiety, has been approved for the treatment of chronic pain. This review surveys over 130 compounds of guanidine-containing secondary metabolites from marine invertebrates with emphasis on their pharmacological significance and structure-activity relationships.

Keywords: Guanidine, marine invertebrates, antimicrobial, antiproliferative, anticoagulant, secondary metabolites, analgesic, Acyclovir, ziconotide, chronic pain, conotoxin MVIIA, Prialt®, Zovirax®

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 11
ISSUE: 3
Year: 2011
Page: [225 - 246]
Pages: 22
DOI: 10.2174/138955711795049862
Price: $58

Article Metrics

PDF: 13