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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles

Author(s): Bruce S. Burnham, Joshua D. Berkowitz, Zachary Orr, Bryan McCranor, Mardel Cooper, Kurt McCann, Kyle Pillitteri, Jodi Hallback, Lisa-Marie Bergh, Larisa Gofman, Melissa Melendez, Justin M. Holub, Kenzo Morie and Charles E. Carraher

Volume 8, Issue 6, 2011

Page: [544 - 549] Pages: 6

DOI: 10.2174/157018011795906839

Price: $65

Abstract

2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.

Keywords: Carboxylic acids, cholesterol, lipids, polymers, pyrroles, triglycerides, Lipid, Halophenyl Pyrroles, Cardiovascular disease, LDL, HDL, ezetimibe, colistipol, total serum cholesterol, regioselective synthesis


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