Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles
Bruce S. Burnham,
Joshua D. Berkowitz,
Justin M. Holub,
Charles E. Carraher.
2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.
Keywords: Carboxylic acids, cholesterol, lipids, polymers, pyrroles, triglycerides, Lipid, Halophenyl Pyrroles, Cardiovascular disease, LDL, HDL, ezetimibe, colistipol, total serum cholesterol, regioselective synthesis
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