Abstract
2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.
Keywords: Carboxylic acids, cholesterol, lipids, polymers, pyrroles, triglycerides, Lipid, Halophenyl Pyrroles, Cardiovascular disease, LDL, HDL, ezetimibe, colistipol, total serum cholesterol, regioselective synthesis
Letters in Drug Design & Discovery
Title: Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles
Volume: 8 Issue: 6
Author(s): Bruce S. Burnham, Joshua D. Berkowitz, Zachary Orr, Bryan McCranor, Mardel Cooper, Kurt McCann, Kyle Pillitteri, Jodi Hallback, Lisa-Marie Bergh, Larisa Gofman, Melissa Melendez, Justin M. Holub, Kenzo Morie and Charles E. Carraher
Affiliation:
Keywords: Carboxylic acids, cholesterol, lipids, polymers, pyrroles, triglycerides, Lipid, Halophenyl Pyrroles, Cardiovascular disease, LDL, HDL, ezetimibe, colistipol, total serum cholesterol, regioselective synthesis
Abstract: 2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.
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S. Burnham Bruce, D. Berkowitz Joshua, Orr Zachary, McCranor Bryan, Cooper Mardel, McCann Kurt, Pillitteri Kyle, Hallback Jodi, Bergh Lisa-Marie, Gofman Larisa, Melendez Melissa, M. Holub Justin, Morie Kenzo and E. Carraher Charles, Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles, Letters in Drug Design & Discovery 2011; 8 (6) . https://dx.doi.org/10.2174/157018011795906839
DOI https://dx.doi.org/10.2174/157018011795906839 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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