Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles

Author(s): Bruce S. Burnham, Joshua D. Berkowitz, Zachary Orr, Bryan McCranor, Mardel Cooper, Kurt McCann, Kyle Pillitteri, Jodi Hallback, Lisa-Marie Bergh, Larisa Gofman, Melissa Melendez, Justin M. Holub, Kenzo Morie, Charles E. Carraher.

Abstract:

2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.

Keywords: Carboxylic acids, cholesterol, lipids, polymers, pyrroles, triglycerides, Lipid, Halophenyl Pyrroles, Cardiovascular disease, LDL, HDL, ezetimibe, colistipol, total serum cholesterol, regioselective synthesis

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2011
Page: [544 - 549]
Pages: 6
DOI: 10.2174/157018011795906839
Price: $58