Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus

Author(s): Oleg V. Ardashov, Vladimir V. Zarubaev, Anna A. Shtro, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Oleg I. Kiselev.

Abstract:

A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.

Keywords: Monoterpenoids, para-menthane, Nicotinate, Influenza, Pandemic, Antiviral, Chemotherapy Drugs, Influenza epidemics, Antiviral Chemotherapy, Melaleuca armillars, Methane Series, Anticonvulsant, Anti parkinsonians activiies, Isonicotinoyl Chloride Hydrochloride,, Chicken Embryos, Erythrocytes

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2011
Page: [375 - 380]
Pages: 6
DOI: 10.2174/157018011794839411
Price: $58