Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Antimalarial Activity of an N-Alkyl Diamine

Author(s): Nicolli B. de Souza, Carlos A. M. Rezende, Marcela S. Toledo, Davi C. Lagatta, Raphaela V. T. de Oliveira, Cristiane F. da Costa, Adilson D. da Silva, Marcio J. M. Alves, Sonia M. N. Cupolilo, Mauro V. de Almeida, Clarice Abramo.

Abstract:

We report in this work the antimalarial activity of N-dodecyl-ethylenediamine (NDEDA). This compound was tested in vivo in a Plasmodium berghei murine model using the 4-day suppressive test in two separate experiments and displayed a very good inhibition of parasite multiplication.

Keywords: Antimalarial activity, Diamines, Malaria, Murine model, Plasmodium berghei, Polyamines, Lethal, Infectious Diseases, Protozoan Parasites, P. falciparum, P. vivax, P. malariae, P. Ovale, Trichomonas vaginalis, Trypanosoma cruzi

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 4
Year: 2011
Page: [371 - 374]
Pages: 4
DOI: 10.2174/157018011794839439
Price: $58