Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives

Author(s): Bothiana A. AbdelFattah, Maha M.A. Khalifa, Hend El-Sehrawi, Eman Fayed, Ashraf Bayoumi, Makarem Said.


A novel synthetic procedure for a series of 4-Aryl-3-phenyl-6,7,8,9-tetrahydro- benzothieno[3,2- f][1,4]oxazepin-5(4H)-one 8a-s derivatives had been described. Six compounds 8a,b,h,j,m,s were selected and submitted to pharmacological evaluation for anxiolytic activity in the open field test. All the test compounds except 8b significantly reduced the exploratory activity and the emotionality of the rats in the open-field. These inhibitory results are in agreement with the effect of reference standard chlorpromazine as a tranquillizer and anxiolytic in the same conditions.

Keywords: Synthesis, 5-Oxo-1, 4-Oxazepine derivatives, Open field test, Anxiolytic activity

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Article Details

Year: 2011
Page: [330 - 338]
Pages: 9
DOI: 10.2174/157018011794839448
Price: $58