Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Characterization of some Novel Quinoxaline-2, 3-Dione Derivatives: A Preliminary Investigation on their Activity Against a Human Epithelial Carcinoma Cell Line

Author(s): Selvaraj Jubie, Rajamanickam Gayathri, Ammayappan Rajam Srividya, Rajagopal Kalirajan, Prabakaran Prabitha, Sundaram Sankar, Kannan Elango.

Abstract:

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid, was reacted with chlorosulphonic acid under cold condition followed by a reaction with various benzimidazoles to give 2, 3- dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl benzimidazoles in satisfactory yield. Their structures were confirmed using 1H NMR, IR and mass analysis. Cytotoxicity of these derivatives were evaluated by growth inhibition of HEp-2 cells in vitro. The preliminary bioassay indicated that these compounds showed moderate cytotoxicity.

Keywords: Benzimidazole, Cytotoxicity, Quinoxaline-2,3-dione, SRB method, Electrophilic substitution, Human epithelial carcinoma cell line, Hetrocycles, Organic Synthesis, Antimalarial Activities, Benzimidazole Derivatives, Pharmacological Activities, Anthelminitic Agents, Veterinarian Medicine, Human Therapeutic Areas, Oxalic acid Dihydrate, Catalyst Microwave System

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2011
Page: [317 - 320]
Pages: 4
DOI: 10.2174/157018011794839385
Price: $58