Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-Ray Absorption Spectroscopy

Author(s): Jade B. Aitken, Aviva Levina, Peter A. Lay.

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 5 , 2011

Abstract:

Most metal-based drugs are pro-drugs; therefore, it is essential that methods are developed to follow their speciation in biological fluids, cells and tissues. This will lead to both a better understanding of the factors that affect their efficacies and toxicities and, consequently, to the design of new and superior drugs. The use of X-ray absorption spectroscopy on bulk samples, and X-ray microprobe techniques on cells and tissues, provides unprecedented information on the biotransformations and biodistributions of metal-containing drugs that is required for a better understanding of their pharmacology. Here the methodologies that have been used on a range of metal- or metalloid-containing drugs and dietary supplements are reviewed, with an emphasis on research conducted within our group. In particular, applications of these techniques to anti-cancer, anti-diabetic, and anti-inflammatory drugs are discussed.

Keywords: Metal-containing drugs, anti-cancer drugs, anti-diabetic drugs and supplements, anti-inflammatory drugs, X-ray absorption spectroscopy, biotransformations, biodistributions, efficacy, complexes, glutathione complex, multiple-scattering contributions, ARSENIC, SELENIUM, XAS and SRIXE techniques

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Article Details

VOLUME: 11
ISSUE: 5
Year: 2011
Page: [553 - 571]
Pages: 19
DOI: 10.2174/156802611794785217
Price: $58

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