Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation

Author(s): Ji-Tai Li , Xiao-Ya Xu , Ying Yin .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 3 , 2011

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Abstract:

Synthesis of 5-arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-arylmethyl-5-phenyl-2-thioxoimidazolidin-4- one) via the reaction of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone and urea (or thiourea) was carried out in 57-98% yields at 50 °C in EtOH in the presence of KOH under ultrasound irradiation. The procedure has the advantages of mild conditions, short reaction time and high yield.

Keywords: Substituted hydantoin, synthesis, chalcone oxide, ultrasound irradiation, seizures, convulsions, epoxyl, methoxyphenyl, propanone, imidazolidine

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [198 - 201]
Pages: 4
DOI: 10.2174/157017811795038403
Price: $58

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