Mild and Efficient Iodine-Catalyzed Direct Substitution of Hydroxy Group of Alcohols with C- and N-Nucleophiles

Author(s): Zhe Liu , Dong Wang , Yongjun Chen .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 1 , 2011

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Abstract:

A mild and efficient iodine-catalyzed direct substitution of hydroxy group of allylic, progargylic and other alcohols with various C- and N-nucleophiles was described in this contribution. C-C and C-N bond formations could be readily achieved by non-metallic and green catalysis for various compounds. This facilitates access to possible transformations of a broad scope of substrates into bioactive and pharmaceutically important building blocks.

Keywords: Allylation, Bond formation, C-, N-nucleophiles, Green chemistry, Iodine, Isomerization, Propargylation, Substitution

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2011
Page: [73 - 80]
Pages: 8
DOI: 10.2174/157017811794557787

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