High-Efficiency Synthesis of Chitooligosaccharides

Author(s): Gangliang Huang.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 1 , 2011

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Abstract:

The solid-phase synthesis of chitooligosaccharides is described. After the NHCbz trichloroacetimidate donors 6 and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The illustrated tetra-Nacetyl- chitotetraose 1 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively.

Keywords: Chitooligosaccharides, solid-phase synthesis, trichloroacetimidate donors, Wang resin, glycosylation reactions

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2011
Page: [70 - 72]
Pages: 3
DOI: 10.2174/157017811794557877

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