Erbin, a Negative Regulator in Diverse Signal Pathways

Author(s): Dan Liu, Ming Shi, Huijun Duan, Caili Han, Ning Guo.

Journal Name: Current Protein & Peptide Science

Volume 11 , Issue 8 , 2010

Submit Manuscript
Submit Proposal

Abstract:

Erbin belongs to the LAP protein family. Originally, Erbin was described as a Her2-interacting protein. Recent studies demonstrated that Erbin could inhibit the Ras-mediated activation of the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and transforming growth factor β (TGF-β) signaling pathways. It suggests that Erbin may function as a signaling molecule. The functions of Erbin in determining cell polarity and cell adhesion have been well described. This review mainly focuses on the recent findings in regulation of signaling pathways by Erbin.

Keywords: Erbin, MAPK, ERK, NF-κB, TGF-β, signal transduction, carbonyl termini, epithelial morphogensis, mutagenesis, velocardiofacial syndrome, down regulation

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 11
ISSUE: 8
Year: 2010
Page: [759 - 764]
Pages: 6
DOI: 10.2174/138920310794557673
Price: $58

Article Metrics

PDF: 14