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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 11
ISSUE: 2
DOI: 10.2174/138955711794519483      Price:  $58









Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses

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Author(s): Xinjian Zhang, Jun Dou and Markus W. Germann
Pages 106-113 (8)
Abstract:
There is a growing consensus that cellular immune responses are associated with the clinical outcome of hepatitis C virus infection (HCV). The development of Tetramer staining, ELISpot, flow cytometry and epitope mapping technologies makes it possible to enumerate, phenotype and assess the proliferation and function of HCV specific T cells; as well as map and predict T cell epitopes and track the evolution of T cell epitopes. Such information is essential for the development of effective therapeutic and prophylactic HCV vaccines. This article summarizes the technical advances relevant to HCV specific T cell responses.
Keywords:
Hepatitis C Virus (HCV), T cell, proliferation, tetramer, ELISpot, epitope mapping, Tetramer staining, flow cytometry, prophylactic HCV vaccines, Flaviviridae virus, Cytotoxicity T LymphocyTE (CTL) Assays
Affiliation:
Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, USA.