A New and Direct Synthesis of Chalcones Via TFAA-H3PO4 Mediated C-C Bond Forming Reaction

Author(s): Kavitha Kankanala , Lingam Venkata Reddy , Vangala Ranga Reddy , Khagga Mukkanti , Sarbani Pal .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 1 , 2011

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Abstract:

A number of α,β-unsaturated carboxylic acids were reacted with electron rich arenes or heteroarene in the presence of trifluoroacetic anhydride (TFAA) and H3PO4 at room temperature to give a variety of chalcone derivatives in good to excellent yields. The methodology was used to prepare novel compounds of potential pharmacological significances.

Keywords: Chalcones, TFAA, α, β-unsaturated carboxylic acids, arenes

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2011
Page: [53 - 59]
Pages: 7
DOI: 10.2174/157017811794557750

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