A New and Direct Synthesis of Chalcones Via TFAA-H₃PO₄ Mediated C-C Bond Forming Reaction

Title: A New and Direct Synthesis of Chalcones Via TFAA-H₃PO₄ Mediated C-C Bond Forming Reaction

Volume: 8 Issue: 1

Author(s): Kavitha Kankanala, Lingam Venkata Reddy, Vangala Ranga Reddy, Khagga Mukkanti and Sarbani Pal

Affiliation:

Keywords: Chalcones, TFAA, α, β-unsaturated carboxylic acids, arenes

Abstract: A number of α,β-unsaturated carboxylic acids were reacted with electron rich arenes or heteroarene in the presence of trifluoroacetic anhydride (TFAA) and H3PO4 at room temperature to give a variety of chalcone derivatives in good to excellent yields. The methodology was used to prepare novel compounds of potential pharmacological significances.

Cite this article as:

Kankanala Kavitha, Venkata Reddy Lingam, Ranga Reddy Vangala, Mukkanti Khagga and Pal Sarbani, A New and Direct Synthesis of Chalcones Via TFAA-H₃PO₄ Mediated C-C Bond Forming Reaction, Letters in Organic Chemistry 2011; 8 (1) . https://dx.doi.org/10.2174/157017811794557750