Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, Characterization of Some New Five Membered Heterocycles Based on Imidazole Moiety and their Applications on Therapeutics

Author(s): V. S.V. Satyanarayana, A. Sivakumar, Asit Ranjan Ghosh.

Abstract:

Different imidazole derivatives were prepared by utilizing the intermediate 2-(2,4,5-triphenyl-1H-imidazol-1- yl)acetohydrazide (3) using microwave irradiation method besides the traditional ones. They were used for synthesis of some new derivatives of 2,5-disubstituted-1,3,4-oxadiazole, pyrazole, 2,5-dimethylpyrrole and nitrogen containing five membered rings. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectral data. The antibacterial, antifungal (MIC) and antioxidant activities were verified for all the synthesized compounds.

Keywords: 2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide, Five membered heterocycles, Microwave irradiation, Antibacterial activity, Antifungal activity, Antioxidant activity

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [276 - 283]
Pages: 8
DOI: 10.2174/157018011794578196
Price: $58