Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer

Author(s): Vinaykumar S. Velingkar, Vikrant D. Dandekar.

Abstract:

A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.

Keywords: Aryl propyl acridone-4-carboxamides, Microwave, Chemosensitizing agents

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [268 - 275]
Pages: 8
DOI: 10.2174/157018011794578169
Price: $58