Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer
Vinaykumar S. Velingkar,
Vikrant D. Dandekar.
A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.
Keywords: Aryl propyl acridone-4-carboxamides, Microwave, Chemosensitizing agents
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