In Silico Studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) Cyclopentanone on Proteins AChE and BChE Involved in Alzheimers disease and Ameliorative Effects on Paraquat Induced Oxidative Stress Markers in Drosophila melanogaster

Title: In Silico Studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) Cyclopentanone on Proteins AChE and BChE Involved in Alzheimers disease and Ameliorative Effects on Paraquat Induced Oxidative Stress Markers in Drosophila melanogaster

Volume: 8 Issue: 3

Author(s): Balladka Kunhanna Sarojini, Chenna Govindaraju Darshan Raj, Modalkoppalu Kyathegowda Ramakrishna, Saraf R Ramesh, Basavapattana Rudresh Bharath and Hanumanthappa Manjunatha

Affiliation:

Keywords: Antioxidant, Alzheimer disease, Bischalcone, Paraquat, Molecular docking, Oxidative stress

Abstract: In the present study, the ameliorative effect of a bischalcone (2E,5E)-2,5-bis(3-methoxy-4-hydroxy- benzylidene) cyclopentanone (CA), a curcumin analog was studied on Drosophila melanogaster (oregon K strain) in vivo by inducing oxidative stress using paraquat. Curcumin (CU) was taken as standard for studies. In negative geotaxis assay it was found that CA was able to rescue the flies significantly from deteriorating locomotor dysfunctions. A docking study for antialzeimers activity of CA was carried out by targeting the proteins Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). It binds effectively to the target proteins.

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Kunhanna Sarojini Balladka, Govindaraju Darshan Raj Chenna, Kyathegowda Ramakrishna Modalkoppalu, R Ramesh Saraf, Rudresh Bharath Basavapattana and Manjunatha Hanumanthappa, In Silico Studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) Cyclopentanone on Proteins AChE and BChE Involved in Alzheimers disease and Ameliorative Effects on Paraquat Induced Oxidative Stress Markers in Drosophila melanogaster, Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578213