Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES)
We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98% inhibition under similar conditions.
Keywords: Estrone sulfatase, Inhibition, Breast cancer, Thiosemicarbazones, Non-steroidal, Non-competitive inhibition
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