Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES)

Author(s): Amit Kumar, Sukriti Singh, Hadi Bordbar, Timothy Cartledge, Sabbir Ahmed.

Abstract:

We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98% inhibition under similar conditions.

Keywords: Estrone sulfatase, Inhibition, Breast cancer, Thiosemicarbazones, Non-steroidal, Non-competitive inhibition

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [241 - 245]
Pages: 5
DOI: 10.2174/157018011794578231
Price: $58