Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan
Tatjana G. Tolstikov,
Mikhail V. Khvostov,
Galina I. Lifshits,
Alexander V. Dushkin,
Elezaveta S. Meteleva.
The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacons anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).
Keywords: Arabinogalactan, Clathration, Glycyrrhizic acid, Warfarin
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