Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Bacterial Secretion Chaperones

Author(s): Juliana Fattori, Alessandra Prando, Adriana Martini Martins, Fabio Henrique dos Santos Rodrigues, Ljubica Tasic.

Abstract:

Many Gram-negative bacteria are able to invade hosts by translocation of effectors directly into target cells in processes usually mediated by two very complex secretion systems (SSs), named type III (T3) and type IV (T4) SSs. These syringe-needle injection devices work with intervention of specialized secretion chaperones that, unlike traditional molecular chaperones, do not assist in protein folding and are not energized by ATP. Controversy still surrounds secretion chaperones primary role, but we can say that these chaperones act as: (i) bodyguards to prevent premature aggregation, or as (ii) pilots to direct substrate secretion through the correct secretion system. This family of chaperones does not share primary structure similarity but amazingly equal 3D folds. This mini review has the intent to present updated structural and functional data for several important secretion chaperones, either alone or in complex with their cognate substrates, as well to report on the common features and roles of T3, T4 and flagellar chaperones.

Keywords: Secretion chaperones, protein and DNA transport, protein-protein interactions, spectrometry and spectroscopy, Gram-negative bacteria, SSs, ATP, DNA, cell cytoplasm, ATPase, E. coli, DnaK/DnaJ, T3SS, T4SS, S. enterica, CesT, VirE2, NMR, MS, Salmonella enterica, SycE, CBD, FliT, EM, SAXS, MALDI, SPI-2, SPR, crystallographySecretion chaperones, protein and DNA transport, protein-protein interactions, spectrometry and spectroscopy, Gram-negative bacteria, SSs, ATP, DNA, cell cytoplasm, ATPase, E. coli, DnaK/DnaJ, T3SS, T4SS, S. enterica, CesT, VirE2, NMR, MS, Salmonella enterica, SycE, CBD, FliT, EM, SAXS, MALDI, SPI-2, SPR, crystallography

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Article Details

VOLUME: 18
ISSUE: 2
Year: 2011
Page: [158 - 166]
Pages: 9
DOI: 10.2174/092986611794475048
Price: $58